Age-dependent changes in islet and beta-cell mass of wild-type and thrombospondin-1 deficient mice.

<p>Micrographs of insulin-stained (red) pancreas from 10–12-week-old wild-type (A) and thrombospondin-1 deficient mice (B), 16-week-old wild-type (C) and thrombospondin-1 deficient mice (D), and one-year-old wild-type (E) and thrombospondin-1 deficient mice (F). Islet, beta- and alpha-cell mass in 10–12 week-old, 16-week-old and one-year-old wild-type and thrombospondin-1 deficient mice (G–I). Number of pancreatic islets in the same animals (J). All values are given as means±SEM for 5–8 animals in each group. * denotes P<0.05 when compared to age-matched wild-type animals. Scale bars in A–F are 400 µm.