PDGF receptor is involved in PDGF-CC neuroprotection.

<p>(<b>A</b>) Expression of PDGF-αR and βR in SH-SY5Y cells by RT-PCR. (<b>B</b>) SH-SY5Y cells were exposed to PDGF-CC (50 ng/ml) for 30 min in presence or absence of tyrosine kinase inhibitor STI-571 (1 µM). Phosphorylation of PDGF-αR & βR was detected by co-immunoprecipitation. (<b>C</b>) Cell viability of SH-SY5Y cells exposed to PDGF-CC and/or Tat in presence or absence of tyrosine STI-571 was assessed by MTT assay. Figure is a representative of three independent experiments. All data in these figures are presented as mean ± SEM of three individual experiments. *p<0.05 vs control, #p<0.05 vs Tat-treated group, %p<0.05 vs PDGF-CC plus Tat-treated group.