Promastigotes with high ecto-nucleotidase activity inhibit NO production by activated macrophages.
- Pauline M. Leite (303089)
- Rodrigo S. Gomes (303090)
- Amanda B. Figueiredo (303091)
- Tiago D. Serafim (303092)
- Wagner L. Tafuri (303093)
- Carolina C. de Souza (303094)
- Sandra A. L. Moura (303095)
- Juliana L. R. Fietto (303096)
- Maria N. Melo (220015)
- Fátima Ribeiro-Dias (303097)
- Milton A. P. Oliveira (303098)
- Ana Rabello (112015)
- Luís C. C. Afonso (303099)
Publication date
February 2013
DOIAbstract
<p>J774-macrophages were infected with promastigotes of <i>L. (V.) braziliensis</i> isolates (5 parasites/cell) for 3 and 72 hr, in presence or not of IFN-γ/LPS. (A) Percentage of infected cells and ATPase activity of promastigotes (nmolPi/10<sup>8</sup> parasites/hr). (B) Number of parasites per infected macrophage. (C) NO production in 72 hr supernatants. Bars represent the mean+SD of two independent experiments performed in duplicates. (*) indicates statistical difference (p<0.05). Statistical analysis was performed by Students's <i>t</i>-test.</p
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