Abnormal thymocyte maturation in LynΔN transgenic mice.

<p><b>A)</b> Representative thymi from 2-week old control and LynΔN mice. Bare scale : 0.5 cm. <b>B)</b> Total thymocyte numbers were determined. Lines indicate the mean, and each symbol represents one individual mouse. <b>C)</b> Total thymocytes from LynΔN and control mice were analyzed by flow cytometry for CD4 and CD8 expression, as shown in this representative flow cytometry profile. <b>D)</b> Proportion and <b>E)</b> number of all thymocyte subsets of 2-week old control and LynΔN mice were quantified; Lines indicate the mean, and each symbol represents one individual mouse<b>.</b> For these experiments, n = 15 for WT and n = 17 for LynΔN mice. P value, Student <i>t</i> test for unpaired data.