M72 olfactory circuit is restored following ablation by methimazole administration.

<p><b>A</b>, Medial view of OE and OB is shown. M72 neurons lie at the dorsal portion of the turbinates, their axons innervate the dorsal aspect of OB were they coalesce into glomeruli. <b>B</b>, No cell bodies can be observed 5 days post lesion. <b>C</b>, Ten days after lesion few M72-positive neurons are observed. X-gal stained axons and glomeruli remained visible on the surface of the bulb. <b>D</b>, 25 days post lesion M72-positive neurons could be observed in the turbinates and their axons have re-innervated the OB. <b>E</b>, After 45 days, M72-positive cell bodies and glomeruli have regenerated almost completely. The pattern of innervation is similar to control animals even though some wandering axons remain visible. <b>F</b>, Cell counts at the turbinates show the time-course of regeneration of X-gal stained cells. Scale bar 500 µm. Mean ± SEM are represented.