The changes of interstitial collagen deposition and hydroxyproline content in the UUO kidneys.

<p>With Masson’s trichrome staining, there is no interstitial collagen deposition in the control kidney (A). Increased Masson stains indicated by blue stain and arrows gradually appear from 4 hUUO (B) and the stains are time-dependently elevated at 8 hUUO (C), 12 hUUO (D), 1dUUO (E), 3dUUO (F), 5dUUO (G) and 7dUUO (H) from representative kidneys. The statistic data of percentage of Masson stains accumulation in the UUO kidneys (n = 10 in each group) is indicated demonstrated in I. The quantitative data of hydroxyproline content (n = 10 in each group) is implicated in J. Significant fibrotic changes are found at 1dUUO-7dUUO. *, <i>P</i><0.05 when compared to the Control (Con) group.