Probabilistic scatterplot of the incremental cost-effectiveness ratio (ICER) between tDMARD and (A) Etanercept, (B) Etanercept+Rituxiumab, (C) Infliximab, (D) Infliximab+Rituxiumab, (E) Adalimumab and (F) Adalimumab+Rituxiumab for a cohort of 1,000 moderate to severe RA patients withan ACR20, ACR50, and ACR70 endpoint, respectively.

<p>The x-axis and y-axisrepresent lifetime incremental QALYsand costs, respectively. Each dot represents the ICER for 1 simulation. Ellipse surrounds 95% of estimates. The solid and dashed lines represent the cost-effectiveness threshold of 3×the per capita GDP of China and Shanghai per QALY gained, respectively. Dots that located below the ICER threshold representcost-effective simulations for the active strategy compared with the tDMARD strategy.