Modafinil treatment prevents METH-induced decrease in TH immunoreactivity in the striatum.

<p>Representative images of the striatum from brains of animals treated with either VEH (A, E), MOD (B, F), METH (C, G) M+M (D, H), scale bar, 500 µm, and their respective higher magnification photomicrographs (A′–H′), scale bar, 10 µm. Brain sections of animals sacrificed 48 hours (A–D) or 6 days (E–H) after the last METH injection were processed for TH immunoreactivity. Note the decrease in intensity and the changes in TH fiber morphology in the METH treated group 6 days after treatment. Average integrated density (% control) was determined in a region of interest in the dorsolateral striatum in mice (n = 4−8) sacrificed 48 hours (I) or 6 days (J) after the last METH injection. Values are expressed as mean ± SEM. Kruskal Wallis ANOVA on ranks, different letters: p<0.05.