Modafinil treatment counteracts METH-induced striatal astroglial activation.

<p>Representative images of the striatum from brains of animals treated with either VEH (A, E), MOD (B, F), METH (C, G), or M+M (D, H), scale bar, 500 µm, and their respective higher magnification photomicrographs (A′–H′), scale bar, 100 µm. Brain sections of animals sacrificed 48 hours (A–D) or 6 days (E–H) after the last METH injection were processed for GFAP immunoreactivity. Percentage of immunoreactive area was determined in mice (n = 5−8) sacrificed 48 hours (I) or 6 days (J) after the last METH injection. Values are expressed as mean ± SEM. One-way ANOVA followed by Tukey, different letters: p<0.01.