<p>Kaplan-Meier survival curves of the indicated genotype of mice. The numbers of mice in each group are denoted by the <i>n</i> values. P values calculated by log-rank test.</p
MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single n...
SummaryMDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A s...
The p19ARF gene product responds to oncogenic stresses by interfering with the inhibitory effects of...
<p>The numbers of mice in each group are denoted by the <i>n</i> values. P value calculated by log-r...
<p>Kaplan-Meier survival curves of the indicated genotype of mice. The numbers of mice in each group...
<p>Kaplan-Meier survival curves of the indicated genotype of mice. The numbers of mice in each group...
<p>A) Kaplan-Meier curve displaying tumor free survival of p53<sup>fl/fl</sup> and p53<sup>R172H</su...
<div><p>(A) Average number of carcinomas per mouse is plotted against the number of weeks postinitia...
<p>Percentages were calculated from the total number of mice analyzed; – indicates no tumors of that...
Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis. Ar...
Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis. Ar...
The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, how...
<p>(A) Kaplan-Meir tumor free survival curve for <i>Rnf8<sup>−/−</sup>p53<sup>+/−</sup></i> mice and...
<p>Western blots to determine endogenous p53 and Mdm2 proteins in the livers of wild-type and <i>SHP...
<p>(A) Kaplan-Meier survival curves are shown for germline p53<sup>−/−</sup> mice in black (n = 72),...
MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single n...
SummaryMDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A s...
The p19ARF gene product responds to oncogenic stresses by interfering with the inhibitory effects of...
<p>The numbers of mice in each group are denoted by the <i>n</i> values. P value calculated by log-r...
<p>Kaplan-Meier survival curves of the indicated genotype of mice. The numbers of mice in each group...
<p>Kaplan-Meier survival curves of the indicated genotype of mice. The numbers of mice in each group...
<p>A) Kaplan-Meier curve displaying tumor free survival of p53<sup>fl/fl</sup> and p53<sup>R172H</su...
<div><p>(A) Average number of carcinomas per mouse is plotted against the number of weeks postinitia...
<p>Percentages were calculated from the total number of mice analyzed; – indicates no tumors of that...
Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis. Ar...
Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis. Ar...
The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, how...
<p>(A) Kaplan-Meir tumor free survival curve for <i>Rnf8<sup>−/−</sup>p53<sup>+/−</sup></i> mice and...
<p>Western blots to determine endogenous p53 and Mdm2 proteins in the livers of wild-type and <i>SHP...
<p>(A) Kaplan-Meier survival curves are shown for germline p53<sup>−/−</sup> mice in black (n = 72),...
MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single n...
SummaryMDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A s...
The p19ARF gene product responds to oncogenic stresses by interfering with the inhibitory effects of...