The <i>fadL</i> and <i>fadD</i> promoters of <i>E. coli</i>.

<p><b><i>A</i></b>. Genomic contexts of <i>fadL</i> and <i>fadD</i> on the <i>E. coli</i> chromosome (the two genes are separated by 570 kb). The transcription start sites (S) are indicated by arrows. Dotted lines denote spanning with long distance. <b><i>B</i></b> and <b><i>C</i></b>. Sequences of the <i>fadL</i> promoter and the <i>fadD</i> promoter, respectively. All the demonstrated sites bound by either FadR or ArcA are labeled with black rectangles, whereas the annotated CRP binding sites that were validated in this study are labeled with blue rectangles. A dotted rectangle labels a <i>fadL</i> CRP binding site incorrectly predicted by EcoCyc (<a href="http://www.ecocyc.org" target="_blank">http://www.ecocyc.org</a>). White letters shaded in red denote the identical residues, red letters shaded in white mean similar bases, whereas white-shaded black letters denote unrelated. Dots denote gaps. “M” denotes the translation initiation site. The numbers are given relative to the transcription start site (S). The <i>fadL</i> and <i>fadD</i> FadR binding sites and their relative spacing are largely conserved in the genomes of <i>Citrobacter</i>, <i>Kelbsiella</i> and <i>Enterobacter</i>.