<p>Squid giant axons were stimulated with our stochastic paradigm consisting of model EPSCs and IPSCs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045983#pone.0045983-Forger1" target="_blank">[1]</a>. The recording from which this result was taken contained 21 spikes (record duration was 100 sec). All 21 spikes are shown superimposed in the top panel using the maximum amplitude of each spike as a reference point. The underlying current waveforms were similarly aligned (middle panel). The average of these results ±2 SEM is shown in the bottom panel. This result is our candidate optimal stimulus waveform.</p
<p>Each panel is scaled on its own extremes; red colors indicate high spike firing levels and blue c...
<p>Sample voltage traces of 2 seconds of simulation of the stochastic HH model with the simulation a...
<p>The clicks were separated by 2 ms and presented at an amplitude of 80 dB. (B) The cumulative hist...
Computing the average input stimulus preceding a spike, the spike-triggered average (STA), has been ...
<p>A) Experimental design of a signal immersed in noise paradigm. Current for injection is composed ...
<p>The subfigures display data for N>200 single APs triggered by identical stimuli and initial condi...
Input noise, defined as the root mean square of the fluctuations in the input, typically limits the ...
The work is made available under the Creative Commons CC0 public domain dedication. The definitive v...
<p>(A) The reference channel (black outline) can be chosen as a single spike-sorted channel or two c...
Information transfer in neurons takes place through action potentials (spikes) which are metabolical...
<p>The conditional mean firing rate of the presynaptic cell given that the postsynaptic cell has fir...
<p>(A) The recording setup. Stimulation currents are applied locally through a stimulation ring, whi...
<p>A) Schematic of phase triggered averaging (PTA) for a single neuron. Times for which the three hi...
<p>(A) Spike triggered average voltage for and firing rates ; simulated results (circles) and anal...
<p>(A) Spikes initiated through a QSC or SNIC bifurcation exhibit different spike amplitude variabil...
<p>Each panel is scaled on its own extremes; red colors indicate high spike firing levels and blue c...
<p>Sample voltage traces of 2 seconds of simulation of the stochastic HH model with the simulation a...
<p>The clicks were separated by 2 ms and presented at an amplitude of 80 dB. (B) The cumulative hist...
Computing the average input stimulus preceding a spike, the spike-triggered average (STA), has been ...
<p>A) Experimental design of a signal immersed in noise paradigm. Current for injection is composed ...
<p>The subfigures display data for N>200 single APs triggered by identical stimuli and initial condi...
Input noise, defined as the root mean square of the fluctuations in the input, typically limits the ...
The work is made available under the Creative Commons CC0 public domain dedication. The definitive v...
<p>(A) The reference channel (black outline) can be chosen as a single spike-sorted channel or two c...
Information transfer in neurons takes place through action potentials (spikes) which are metabolical...
<p>The conditional mean firing rate of the presynaptic cell given that the postsynaptic cell has fir...
<p>(A) The recording setup. Stimulation currents are applied locally through a stimulation ring, whi...
<p>A) Schematic of phase triggered averaging (PTA) for a single neuron. Times for which the three hi...
<p>(A) Spike triggered average voltage for and firing rates ; simulated results (circles) and anal...
<p>(A) Spikes initiated through a QSC or SNIC bifurcation exhibit different spike amplitude variabil...
<p>Each panel is scaled on its own extremes; red colors indicate high spike firing levels and blue c...
<p>Sample voltage traces of 2 seconds of simulation of the stochastic HH model with the simulation a...
<p>The clicks were separated by 2 ms and presented at an amplitude of 80 dB. (B) The cumulative hist...