Effect of Se-lactoferrin eye drops on production of 8-OHdG in corneas.

<p>A, B: Immunohistochemical staining of corneas of normal (A) and dry eye (B) rats using an anti-8-OHdG antibody. C,D: Immunohistochemical staining of corneas of dry eye rats treated with PBS (C) or 0.1% Se-lactoferrin (D) using anti-8-OHdG antibody. Scale bar shows 20 µm. Original magnification: x20. E: Relative ratio of 8-OHdG in corneas of normal, dry eye, dry eye treated with PBS or dry eye treated with 0.1% Se-lactoferrin rat. The vertical axis shows 1/brightness ratio. The brightness ratio in the normal group was defined as 1. Results are expressed as the mean ± S.D. (n = 4). Dunnett’s test was used to determine the significance of differences. *** indicate a significant difference from the results in normal or PBS treatment group, P<0.005.