Hair follicle placode formation is impaired without Wls.
- Sixia Huang (306146)
- Xuming Zhu (306147)
- Yanfang Liu (306148)
- Yixin Tao (306149)
- Guoyin Feng (165438)
- Lin He (102807)
- Xizhi Guo (188555)
- Gang Ma (52569)
Publication date
February 2013
DOIAbstract
<p>(A and D) <i>Shh</i> positive placodes are decreased in <i>Wls</i>-deficient skin compared with the control. (B and E) <i>Bmp4</i> expressing dermal condensates are reduced in <i>K14-cre;Wls<sup>c/c</sup></i> mutants. (C and F) <i>Lef1</i> positive placodes decrease significantly in <i>Wls</i>-deficient skin. (G) Statistical analysis of the <i>Shh</i>, <i>Bmp4</i> and <i>Lef1</i> positive spots in embryo skin. **, P<0.01; *, P<0.05. cKO, <i>K14-cre;Wls<sup>c/c</sup></i>.</p
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