The frequencies of candidate genetic loci.

<p>The most common allele for each locus is underlined.</p><p>Abbreviation: HWE, Hardy–Weinberg equilibrium.</p>a<p>Comparison between our data and Western data with pediatric ALL. Data for 15 loci was adopted from Ref. 10 and data of <i>ITPA</i> 94 C>A was from Ref. 9.</p>b<p>Comparison between our data and normal Japanese data. Reference data was adopted by SNP searching on NCBI reference assembly (<a href="http://www.ncbi.nlm.nih.gov/snp/" target="_blank">http://www.ncbi.nlm.nih.gov/snp/</a>). Data for <i>CYP3A4*1B</i> was from Coriell Cell Repository samples and all the others were from Japanese data of the Hapmap project.</p>c<p>Hardy-Weinberg equilibrium was reached after the A variant was excluded (<i>P</i> = 0.38).</p>d<p>Variant alleles : <i>TPMT*1</i> (Wild type), <i>TPMT*2</i> (238 G>C), <i>TPMT*3A</i> (460 G>A and 719 A>G), <i>TPMT*3B</i> (460 G>A), <i>TPMT*3C</i> (719 A>G).