Infectivity of cancer cells with the adenovirus displaying the selected peptide.

<p>(a) Luciferase activities following infection of adenovirus vectors <i>in vitro</i>. The AsPC-1, PSN-1, SKOV3 and MKN45 cells were infected with adenovirus vectors (AdΔCAR-LucEGFP-PFW, AdΔCAR-LucEGFP-SYE, AdΔCAR-LucEGFP or Ad-LucEGFP), and 24 h later the luciferase activities were measured. (b) Competitive inhibition of transduction of the adenovirus vector with selected peptide. Transduction efficiencies of AdΔCAR-LucEGFP-PFW in AsPC-1 cells were evaluated at moi 30 in the presence of the cognate or a control unrelated peptide at 0.2–1.5 mmol/L. The data are expressed as the relative luciferase activity (luciferase activity in the presence of peptide/that in the absence of peptide). Control peptide: AQGQWAL.