Cardiomyocyte expression of the p110α transgene attenuated tissue NFкB activity in response to CLP sepsis.

<p>Lung (<b>A</b>) and spleen (<b>B</b>) NFкB activity are shown at the top. caPI3K mice and age-matched WT mice were subjected to CLP. Lung tissue was harvested 16 hrs after CLP. *p<0.05 vs WT control; **p<0.05 vs WT CLP group. (n = 4/group). Cardiac specific expression of PI3K p110α attenuated myeloperoxidase activity in the heart (<b>C</b>) and lung (<b>D</b>) in response to sepsis. caPI3K mice and age-matched WT mice were subjected to CLP. Heart and lung tissue was harvested 16 hrs after CLP. (n = 4–6/group). ^*p<0.05 vs WT; ^**p<0.05 vs caPI3k control; ^#p<0.05 vs WT CLP; ⁺p<0.05 vs caPI3k sham. <b>E.</b> Lung caspase 3/7 activity was increased in wild type, but not caPI3K Tg, mice in response to CLP sepsis. caPI3K mice and age-matched WT mice were subjected to CLP. Lung tissue was harvested 16 hrs after CLP. (n = 4–6/group). *p<0.05 vs WT control; **p<0.05 vs WT CLP group.