Kaplan-Meier Survival curves of GBM patients dichotomized according to PNL vs. CL classification.

<p>(A) The overall survival was significantly higher for GBM patients of PNL subtype compared to patients of CL subtype (p = 0.047). (B) For GBM patients of the CL subtype, the addition of temozolomide to radiotherapy significantly improved the patient's overall survival (p = 0.002), but radiotherapy alone exhibited no significant effect when compared with palliative management or no treatment (p = 0.15). (C) For GBM patients of the PNL subtype, radiotherapy alone significantly improved the overall patient's survival when compared to palliative management or no treatment (p = 0.0014), but the addition of temozolomide conferred no significant effect when compared to radiotherapy alone (p = 0.51).