Distance travelled.

<p>Locomotor activity in the hour following dosing in rats given their first or tenth daily dose of methamphetamine (METH, 2.5 mg/kg) or mephedrone (MMC, 30 mg/kg). Error bars represent + S.E.M. On the first day (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045473#pone-0045473-g002" target="_blank">Figure 2A</a>), the two drug treated groups (MMC×10 and METH×10) travelled greater distance than the three vehicle-treated groups (P<0.01, indicated by ++). On day 10 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045473#pone-0045473-g002" target="_blank">Figure 2B</a>) both the combined METH groups and the combined MMC groups travelled greater distance than the VEH group (P<0.01, indicated by *). A logarithmic transformation was applied to the data due to heterogeneity of variance.