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Schematic diagram for the <sup>111</sup>In-AP-1 Lipo-Dox.

  • Feng-Yi Yang (289534)
  • Hsin-Ell Wang (307175)
  • Ren-Shyan Liu (170072)
  • Ming-Che Teng (307178)
  • Jia-Je Li (307180)
  • Maggie Lu (307182)
  • Ming-Cheng Wei (307185)
  • Tai-Tong Wong (48446)
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Publication date
February 2013
Icon DOI
10.1371/journal.pone.0045468.g005

Abstract

<p>Liposomes were prepared containing maleimide-functional polyethylene glycol chains. The maleimide was used to attach the AP-1 peptide through the thiol group on a cystine. <sup>111</sup>In label was introduced into the liposomes. Therapeutic liposomes were loaded with Dox. DSPE-PEG2000 = 1,2-distearoyl-<i>sn</i>-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000], MAL = maleimide.</p

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