IN dimerization interface mutations inhibit HIV-1 replication after early stage.

<p>(A) Exogenous reverse transcriptase activity assay of WT and mutant NL4.3 viruses. (B) Viral breakthrough assay measuring replicative competence over a course of six days. WT virus properly reproduced to reach a p24 measurement of >1×10⁶pg/mL at the 144 hour time point, while each mutant virus was incompetent for viral replication.