Molecular & Biological Pathway Interaction Map Analysis upon Diabetes induction with or without disruption of B₂R.

<p>Using Pathway Studio 9.0, altered genes relevant to diabetic induction with or without disruption of B₂R. were analyzed. In B₂R^−/−D vs. B₂R^+/+D mice, a total of 109 genes were found to be altered (43 upregulated and 66 downregulated). The network was generated using “direct interaction” algorithm to map cellular processes and interactions among altered genes. Of interest, global Pathway analysis revealed association of these genes to oxidative stress mechanisms (ROS generation & oxidative stress), cardiac injury mechanisms along with pronounced inflammatory process with a marked alteration in the pro-apoptotic genes. The upregulated genes are shown in green and downregulated genes are in red.