The Overall Fold of VldE.

<p>Shown is the overall fold of VldE as well as comparison to OtsA by superimposition. (<b>A</b>) The overall fold of the monomeric VldE is represented in a ribbon diagram. The monomer is rendered with the N-terminal domain in red, and the C-terminal domain in blue. The α-helical C-terminus, which stretches back across both domains, is rendered in green. VldE consists of twin Rossman-like β/α/β domains in a GT-B configuration with the catalytic site marked by VDO and GDP at the interface of the two domains. (<b>B</b>) To compare the overall fold of VldE (green) to OtsA (gray), the folding patterns, which were represented by a tracing of C^α, were superimposed. (<b>C</b>) Shown is a topology diagram of VldE with β-strands and α-helices labeled. Blue boxes identify the core β-sheets of the N- and C-terminal Rossman domains as well as the unique β-hairpin motif.