<p>Mice were treated with 30 mg/kg AS605240 by oral gavage beginning on the day of disease onset on a mouse-to-mouse basis. 2 independent experiments, using a total of 10 mice per group, were performed. Recovery indicates the percentage of mice that returned to a clinical score of 0 after disease onset. Peak disease represents the first day an animal reached its highest recorded clinical disease score and data are shown as mean ± s.d.</p
<p>(A) EAE clinical scores are shown for both vehicle and BIX02694 groups (n = 10 mice per group). (...
<p>EAE was induced actively with MOG<sub>35–55</sub> in complete Freund's adjuvant in MK2<sup>−/−</s...
<p>A. EAE treated with B20-4.1.1. B. Treatment with K(1-3). C. Treatment with IgG. Arrows indicate t...
<p>Data are shown as mean ± s.d. Day of disease onset is the day an animal first displayed clinical ...
<p>EAE was induced in WT mice and these were treated with 30 mg/kg AS605240 or vehicle control by or...
<p>Daily clinical score (A), maximal score (B) and cumulative score (C) of the PBS- and berberine-tr...
<p><b>(A)</b> Mean clinical score of four independent experiments testing the preventive potential o...
<p>Thirty-six mice were immunized with MOG, and 4 mice were sacrificed at day 18 for baseline histol...
<p>C57BL/6 mice were treated with 20 mg/Kg of body weight/day of anatabine directly dissolved in the...
<p>The clinical course of EAE in IP7e (n = 8) and vehicle (n = 9) –treated EAE mice is compared. The...
<p>For treatment of acute disease PLP<sub>139–151</sub>-induced EAE mice were randomized into two gr...
(A) Experimental plan for the EAE prevention study with GlcNAc-6-acetate (G-6-A). (B-E) Mgat5+/- mic...
<p>Male C57BL/6 mice were immunized with MOG-35-55/CFA/Ptx. Mice were scored for clinical signs of E...
<p>R037 (0.8 mg/ml; n = 16) or PBS (n = 17; control) were administered in a water bottle to C57BL/6 ...
<p>The clinical course of EAE in IP7e (n = 9) and vehicle (n = 10) -treated EAE mice is compared. Th...
<p>(A) EAE clinical scores are shown for both vehicle and BIX02694 groups (n = 10 mice per group). (...
<p>EAE was induced actively with MOG<sub>35–55</sub> in complete Freund's adjuvant in MK2<sup>−/−</s...
<p>A. EAE treated with B20-4.1.1. B. Treatment with K(1-3). C. Treatment with IgG. Arrows indicate t...
<p>Data are shown as mean ± s.d. Day of disease onset is the day an animal first displayed clinical ...
<p>EAE was induced in WT mice and these were treated with 30 mg/kg AS605240 or vehicle control by or...
<p>Daily clinical score (A), maximal score (B) and cumulative score (C) of the PBS- and berberine-tr...
<p><b>(A)</b> Mean clinical score of four independent experiments testing the preventive potential o...
<p>Thirty-six mice were immunized with MOG, and 4 mice were sacrificed at day 18 for baseline histol...
<p>C57BL/6 mice were treated with 20 mg/Kg of body weight/day of anatabine directly dissolved in the...
<p>The clinical course of EAE in IP7e (n = 8) and vehicle (n = 9) –treated EAE mice is compared. The...
<p>For treatment of acute disease PLP<sub>139–151</sub>-induced EAE mice were randomized into two gr...
(A) Experimental plan for the EAE prevention study with GlcNAc-6-acetate (G-6-A). (B-E) Mgat5+/- mic...
<p>Male C57BL/6 mice were immunized with MOG-35-55/CFA/Ptx. Mice were scored for clinical signs of E...
<p>R037 (0.8 mg/ml; n = 16) or PBS (n = 17; control) were administered in a water bottle to C57BL/6 ...
<p>The clinical course of EAE in IP7e (n = 9) and vehicle (n = 10) -treated EAE mice is compared. Th...
<p>(A) EAE clinical scores are shown for both vehicle and BIX02694 groups (n = 10 mice per group). (...
<p>EAE was induced actively with MOG<sub>35–55</sub> in complete Freund's adjuvant in MK2<sup>−/−</s...
<p>A. EAE treated with B20-4.1.1. B. Treatment with K(1-3). C. Treatment with IgG. Arrows indicate t...