Development of liver cell tumors (HCC) in PML- HCV+ mice.

<p>The Gomori staining (A) and H&E (B) of the specimens demonstrate that no fibrotic changes have occurred during tumor development. Immunohistochemistry indicates a high expression of glutamine synthetase in most HCCs, however only pericentral expression was observed in the peritumorous tissue area (C). PCNA staining revealed a high proliferation rate in the HCC (D). The dashed border lines show the intersection between the HCC and the peritumorous tissue areas. The lower pictures were high magnification of the squared areas in the upper pictures in the figure legends.