Effect of D, L-sulforaphane (SFN) administration on cleaved Notch1, cleaved Notch2, and HES-1 proteins <i>in vivo</i>.

<p>(A) Representative immunohistochemical images depicting expression of cleaved Notch1, cleaved Notch2, and HES-1 proteins in the prostatic intraepithelial neoplasia (PIN), well-differentiated prostate cancer (WD), and poorly-differentiated prostate cancer (PD) in the dorsolateral prostates from TRAMP mice of the indicated groups (×200 objective magnification). (B) Quantitation of expression (combined analysis in PIN, WD, and PD) is shown as H-score (mean ± SD; n = 5). Statistical significance was determined by Student's <i>t</i>-test.