<i>axin1</i> but not <i>axin1(Q162A)</i> rescues telencephalic defects in Axin-depleted embryos.

<p>(<b>A–D</b>) Representative examples of <i>pax6</i> expression in control and Axin1-depleted <i>Xenopus</i> embryos. Arrows indicate the presumptive telencephalon region of the eye field, visible as a narrowed medial notch in the area of <i>pax6</i> expression. (<b>A</b>) Control uninjected stage 20 embryo, (<b>B</b>) Axin1-depleted embryo (20 ng <i>axin1</i>-MO), (<b>C</b>) MO injected embryo coinjected with 60 pg <i>axin1</i> mRNA, (<b>D</b>) MO injected embryo coinjected with 60 pg <i>axin1(Q162A)</i> mRNA. (<b>E</b>) Summary table of <i>pax6</i> expression data.