Comparison of plasma IL-6, IL-1β and HMGB1 levels in mutant and wild type mice.

<p>(<b>A</b>) Plasma levels (mean ± SD) of IL-6, (<b>B</b>) IL-1β and (<b>C</b>) HMGB1 are compared with mutant and wild type mice at the onset of heatstroke (T0) and at T0+0.5, +1, +4 and +24 hours post heatstroke. Plasma levels from sham-heated animals’ represent baseline. *P<0.05; **P<0.001; and ***P<0.0001 statistical significance at given time points between the two groups tested by the generalized estimating equations model.