Effect of signaling cascade inhibitors on BDNF enhancement of peak [Ca²⁺]_i responses in human ASM cells.

<p>Overnight incubation of ASM cells with either PD98059 or SN50 in the presence of BDNF substantially blunted the enhanced peak [Ca²⁺]_i responses observed with BDNF only for both histamine (A, B) and ACh (C, D). In summary graphs (B, D), *Significant difference from control; #Significant effect of inhibitor. Values are means ± SE (n = 4 patients).