Protein-RNA contacts outside of the active site.

<p>(a) The substrate strand, which leads into the active site, forms hydrogen bonds to the NP through the phosphate backbone and by contacts to G8. D426 hydrogen bonds to its nitrogenous base, and the main chain nitrogen of G392 makes hydrogen bonds to the 2′ and 3′OH of its ribose sugar. (b) The non-substrate strand forms hydrogen bonds between the 2′OH of C1 and Q425, and the 2′OH of C4 and D465. There is also a base stacking interaction between C1 and Y429.