Simulated cell segregation at the density of real cells.

<p>Bottom left: high-density cells (950/field) simulated over the time interval 2500–5500 spanning the observed degree of segregation mediated by cadherins (lower solid blue line). Top right: medium-density cells (590/field) simulated over the interval (14500–16500) spanning the observed segregation seen for Eph/ephrin cells (upper solid blue line). The intersect of the simulated data (red) and observed values (blue) is marked by a black dot at 4000 and 15500 for the cadherin and Eph/ephrin cell lines, respectively. The dashed blue lines represent confidence intervals for the observed data (discussed below). The data for 500 cells/field from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043226#pone-0043226-g003" target="_blank">Figure 3</a> is plotted for reference (green crosses).