Antitumor effect of combined H101-Notch1-siRNA treatment in an OCM1 tumor xenograft mouse model.

<p>(A) Tumor volume following treatments. Subcutaneous tumors were established by implanting OCM1 cells in nude mice (n = 10). (B) Tumor weight on day 24 after first injection (n = 5). (C) Representative pictures of tumor specimens of each treatment group 24 days after first injection. (D) Percentage of mouse survival over 120 days (n = 5). Percent survival was analyzed by Kaplan-Meier survival analysis. Data represent mean ± SD. (**: p<0.01, ***: p<0.001, compared with control group).