Fcoidan inhibited the tumor angiogenesis in vivo.

<p>Representative photographs of the tumor sections examined by immunohistochemical staining for CD34 showing tumor vasculature (×400). The microvessel number was reduced apparently in the tumors belonging to the mice treated with fucoidan. Each bar represents the average vessel number for each group, expressed as mean ± SD. *<i>P</i><0.05 vs Control.