Transcriptional profile of interneuron markers.

<p>Gene expression of parvalbumin (Pvalb), calretinin (Calb2), neuropeptide Y (NPY), choline acetyltransferase (Chat), and neuronal nitric oxide synthase (Nos1) was measured in striatum of PGC-1α and R6/2 HD mice and littermate controls at four and twelve weeks using q-RT-PCR. <b>A.</b> At four weeks of age, Pvalb was significantly decreased in PGC-1α ^−/− and ^+/− compared to ^+/+ mice, and Calb2 was significantly increased in PGC-1α ^−/− compared to ^+/+ and ^+/− mice. <b>B.</b> No changes in interneuron markers were observed in R6/2 HD mice at this age. <b>C.</b> At twelve weeks of age, Pvalb was still significantly decreased in PGC-1α ^−/− and ^+/− compared to ^+/+ mice, and expression of NPY was significantly increased in ^−/− and ^+/− compared to ^+/+ mice. <b>D.</b> In the R6/2, all interneuron markers except Pvalb were significantly decreased at this age. For A and C, one-way ANOVA followed by Fisher's LSD. For B and D, two-tailed t-tests. *p<0.05. **p<0.005. ***p<0.0005. n/group indicated on histograms. Data presented as mean ± SEM.