BLA LTP and antagonist pretreatment in undisturbed mice.

<p><b>A</b> HFS evoked potent and stable LTP at BLA synapses in all experimental groups. Compared to vehicle injected mice (n = 15, white circles), BLA LTP was not affected by propranolol (n = 6, blue circles) or mifepristone pretreatment (n = 6; grey circles). Pretreatment with spironolactone (n = 7, red circles) however gradually attenuated LTP induced some hours later in vitro. <b>C</b> Bar chart illustrating the averages per treatment group for 0–10 min and <b>D</b> 50–60 min of the post-tetanus period, showing attenuated LTP in spironolactone treated mice at the later time-point. Dashed line indicates pre-tetanus baseline values. Error bars indicate SEM. Tukey's post hoc test * p<0.05, ** p<0.01.