Histology from lungs harvested on day 0, 30 and 60 following intrabronchial administration of M5/114 (MHC class II Ab) or LTF-2 (isotype control) to C57BL/6 mice on day 1,2,3,6 and weekly.

<p>(A–F) represent lungs analyzed by H&E staining; (G–L) represent lungs analyzed by trichrome staining; and (M) represents morphometric analysis performed using NIS-Elements BR software to quantitate the epithelial hyperplasia, cellular infiltration, fibrosis, luminal occlusion and neutrophil infiltration (assayed by myeloperoxidase activity). The data is represented as a mean ± SEM over a 5 different animals in each group, the significance (<i>p</i>-value <0.05) was determined by student-t-test and represented with an asterisk (*).