Hypoxia alters blood flow in APP−/− mice.

<p>(A) Blood flow as detected by laser speckle imaging (LSI) decreased in the APP−/− mice but increased in the non-transgenic control mice subjected to a hypoxic challenge. (B) Quantification of the average change in blood flow measured by LSI revealed a significant difference between the reaction of the APP−/− mice and the control mice to hypoxia. (C) There was no difference in the reaction of the APP−/− mice and control mice to hypercapnia measured by LSI, fractional change was confirmed by quantification (D). (E) Demonstration of the area of interest quantified in each animal.