3xTg-AD/BDNF^+/− and 3xTg-AD/BDNF^+/+ mice have comparable levels of Aβ and tau pathology.

<p>No differences between groups were detected by ELISA in levels of Aβ_1–40 or Aβ_1–42 in soluble (<b>A</b>, <i>n = </i>4) or insoluble (<b>B</b>, <i>n = </i>4) fractions. (<b>C</b>) Representative maximum intensity projections of immunofluorescently labeled Aβ and tau in CA1 and cortex indicate a similar pattern of immunoreactivity between 3xTg-AD/BDNF^+/+ and 3xTg-AD/BDNF^+/− mice. Scale bars = 20 μm. Western blot analyses suggest 3xTg-AD/BDNF^+/+ and 3xTg-AD/BDNF^+/− mice have similar levels of proteins related to Aβ production (<b>D–E</b>, <i>n = </i>6) and similar levels of tau and various tau phospho-epitopes (<b>F–G</b>, <i>n = </i>6). Data are presented as means ±SEM.