ADAM10^Δ/ΔIgG1-cre^+/− mice show impaired primary antibody responses.

<p>ADAM10^Δ/ΔIgG1-cre^+/− (▪) and controls (□) were immunized with a T-dependent antigen, NP-KLH, emulsified in alum (A–B) or a T-independent antigen, NP-LPS (C–D). At the indicated times, serum samples were collected and NP-specific antibodies were measured by capture ELISA. Bars represent the mean ± SE of 5–9 mice per group (*p<0.05, **p<0.01). Data represent results obtained in at least two independent experiments.