Plasma cells isolated from ADAM10^Δ/ΔIgG1-cre^+/− mice express Bcl6.

<p>ADAM10^Δ/ΔIgG1-cre^+/− and controls were immunized with NP-KLH emulsified in alum. Twenty-one days following immunization, splenic plasma cells were analyzed by Bcl6 protein expression via flow cytometry. (A) Plasma cells were defined as CD138⁺B220^lo/−. After gating on these cells, they were analyzed for (B) non-specific (isotype) or (C) Bcl6-specific staining. (D) Frequency of Bcl6⁺ cells of plasma cells. Bars represent the mean ± SE of 4–5 mice. (**p<0.01).