Evaluation of ADM as a prognostic factor in ovarian cancer patients.

<p>Kaplan-Meier analysis of 220 ovarian cancer patients (A) revealed that high expression levels of ADM were related to a positive outcome in terms of OS, although the difference did not achieve statistical significance (<i>p</i> = 0.07). The same analysis, with a final endpoint of PFS, revealed the same trend (B), ie, patients with lower expression of ADM relapsed earlier than those with higher levels (<i>p</i> = 0.01). Multivariate analysis showed that age, clinical stage, histotype, and grading were not significantly related to ADM expression, while there was a strong significant inverse association (<i>p</i><0.001) between levels of Ca125 and ADM expression (C). Also, levels of the PLK1 gene, which is related to the number of cells in M phase, were significantly reduced in the group with low ADM expression (D).