Changes in PEPCK and G6Pase expression in the liver 4 weeks after the removal of OA.

<p>Four weeks after the cessation of OA treatment, mice were sacrificed following a 5–7 hour fast. Liver samples were freeze-clamped and stored for subsequent analysis of PEPCK and G6Pase RNA expression. The expression levels of PEPCK and G6Pase mRNA relative to 18S (<i>A</i> and <i>B</i>). Correlation of p-Akt/GAPDH and FoxO1/GAPDH with G6Pase mRNA expression in T2D-Veh and T2D-OA groups by a best-fit regression analysis (<i>C</i>). * p<0.05 vs. CH, n = 6–8 per group. Proposed mechanism for the sustained reduction in hyperglycemia following the treatment of OA (<i>D</i>).