Correlation between PARP activity and aging in (A) Males (B) Females.

<p>(<b>A</b>) <b>PARP activity increases with age in male subjects.</b> PARP activity increases significantly in male subjects aged between 0–77 years (line a; p<0.0001; n = 27). The data including the post-pubescent subjects (males only) shows no significant change in PARP activity with age (line b; p = 0.0913; n = 19). Pearson's correlation coefficient was a normally distributed population was r = 0.768 and r = 0.399 for line a, and line b respectively. An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (<b>B</b>) <b>PARP activity with age in female subjects (n = 27).</b> The apparent increase in PARP activity with age (36–76 years) is not statistically significant in post-pubescent female subjects (p = 0.4390; n = 22). Spearman's Correlation coefficient for a non-normally distributed population was r = 0.174. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.