TLR3/7/8 activation in mice caused pregnancy-dependent hypertension and endothelial dysfunction.
- Piyali Chatterjee (313871)
- Laura E. Weaver (313872)
- Karen M. Doersch (313873)
- Shelley E. Kopriva (313874)
- Valorie L. Chiasson (313875)
- Samantha J. Allen (313876)
- Ajay M. Narayanan (313877)
- Kristina J. Young (313878)
- Kathleen A. Jones (313879)
- Thomas J. Kuehl (313880)
- Brett M. Mitchell (313881)
Publication date
February 2013
DOIAbstract
<p>Measures of (A) systolic blood pressure, (B) aortic endothelium-dependent relaxation induced by acetylcholine, and (C) aortic endothelium-independent relaxation induced by sodium nitroprusside in non-pregnant (top panels) and pregnant (bottom panels) mice treated with TLR3 agonist poly I:C, the TLR7 agonist R837, or the TLR7/8 agonist CLO97. Results are expressed as mean ± SEM and the n is given in parentheses. *p<0.05 vs P.</p
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