Skeletal Phenotype of WT and MC4RKO Mice at 40 Weeks.

<p>The skeletal phenotype of forty-week-old female WT (n = 11) and MC4RKO mice (n = 12) was examined by DEXA and microtomography. Bone strength was determined by 3 point bending to failure. Vertebral morphometric variables describing bone microstructure were computed using direct 3D methods. Values are represented as mean ± SEM. Statistical significance was assessed by Students t-test, with significant differences assigned a p value<0.05.