<p>Note gene is the best proximal candidate or closest gene to the locus and may not be the true pathologically important species. Notably the power to detect association at these loci, based on previously published effect sizes, p<5E-8, and an additive model is effectively 0 (based on methodology of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041859#pone.0041859-Skol1" target="_blank">[17]</a>). MAF, Minor Allele Frequency; OR, odds ratio; CI, confidence interval; IQ, Imputation quality from MACH (RSQR metric).</p
Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alternative ...
<p>SNP, single nucleotide polymorphism; Chr, chromosome; bp, base pair; MAF, minor allele frequency ...
<p>Association results for the Discovery, Replication and combined Meta-analysis, for SNPs with <i>P...
*<p>Abbreviations and definitions are given in <a href="http://www.plosone.org/article/info:doi/10.1...
<p>Power is measured across one hundred simulations of phenotypic effects at each of 24 human gene l...
<p><b>Note:</b> MAF, minor allele frequency. UTR, untranslated region;</p>a<p>Odds ratio followed by...
<div><p>Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alterna...
<p>NOTE: P values <0.10 are shown in bold, while those <0.05 are also underlined. Results are report...
Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alternative to ...
<p>Box plot of the minor allele frequency for all associated variants in the different scenarios. Al...
<p> <i>Footnote: rsid – SNP id; chr – chromosome; maf – minor allele frequency; gene...
a<p>mtDNA position according to rCRS <a href="http://www.plosone.org/article/info:doi/10.1371/journa...
*<p>MAF – minor allele frequency.</p>**<p>number of subjects included in the analysis.</p>***<p>p-va...
a<p>MAF: Minor allele frequency of the reference population is listed;</p>*<p>Benjamini-Hochberg Fal...
1<p>minor allele2</p><p>minor allele frequency.</p>3<p>p-value corrected with Bonferroni correction....
Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alternative ...
<p>SNP, single nucleotide polymorphism; Chr, chromosome; bp, base pair; MAF, minor allele frequency ...
<p>Association results for the Discovery, Replication and combined Meta-analysis, for SNPs with <i>P...
*<p>Abbreviations and definitions are given in <a href="http://www.plosone.org/article/info:doi/10.1...
<p>Power is measured across one hundred simulations of phenotypic effects at each of 24 human gene l...
<p><b>Note:</b> MAF, minor allele frequency. UTR, untranslated region;</p>a<p>Odds ratio followed by...
<div><p>Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alterna...
<p>NOTE: P values <0.10 are shown in bold, while those <0.05 are also underlined. Results are report...
Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alternative to ...
<p>Box plot of the minor allele frequency for all associated variants in the different scenarios. Al...
<p> <i>Footnote: rsid – SNP id; chr – chromosome; maf – minor allele frequency; gene...
a<p>mtDNA position according to rCRS <a href="http://www.plosone.org/article/info:doi/10.1371/journa...
*<p>MAF – minor allele frequency.</p>**<p>number of subjects included in the analysis.</p>***<p>p-va...
a<p>MAF: Minor allele frequency of the reference population is listed;</p>*<p>Benjamini-Hochberg Fal...
1<p>minor allele2</p><p>minor allele frequency.</p>3<p>p-value corrected with Bonferroni correction....
Gene-based tests of association are frequently applied to common SNPs (MAF>5%) as an alternative ...
<p>SNP, single nucleotide polymorphism; Chr, chromosome; bp, base pair; MAF, minor allele frequency ...
<p>Association results for the Discovery, Replication and combined Meta-analysis, for SNPs with <i>P...