Anti-tumor effect on TLT-tumor-bearing mice treated with PTX-loaded micelles in combination with irradiation.

<p>(A) Anti-tumor effect. PTX is administered at a dose of 80 mg/kg. Six groups of mice were treated: Group 1: PBS injection (<i>n</i> = 6); Group 2: PTX-loaded micelles (<i>n</i> = 6); Group 3: Irradiation with 10 Gy of X-rays (<i>n</i> = 6); Group 4: PTX-loaded micelles 24 h before irradiation with 10 Gy of X-rays (<i>n</i> = 8); Group 5: PTX-loaded micelles 24 h before irradiation with 10 Gy of X-rays. The irradiated legs of mice were clamped (<i>n</i> = 7); Each point represents the mean of tumor size ± SEM. (B) Survival rates of tumor-bearing mice. (C) Individual evolution of the TLT growth as a function of time. ** <i>p</i><0.001; ***<i>p</i><0.0001.