<p>The data presented piece-wise in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038275#pone-0038275-g003" target="_blank"><b>Figures 3D</b></a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038275#pone-0038275-g004" target="_blank"><b>4D</b></a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038275#pone-0038275-g005" target="_blank"><b>5F, and 5G</b></a> were transformed to set the first and last values (frequency = 0 and 1) to zero in accord with the known low levels (below detection) of these cyclins at the end and beginning of the cell cycle (<b>C</b>). The functions in (<b>A</b>) and (<b>B</b>) were then used to transform the data in (<b>C</b>) to the form in ...
<p><b>A</b>: Schematic derived from the Csikasz-Nagy model <a href="http://www.plosone.org/article/i...
<div><p>Few of >150 published cell cycle modeling efforts use significant levels of data for tuning ...
<p>(A). Cell cycle profiles showing the distribution of cells in the different phases of the cell cy...
<p>This figure is analogous to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone...
Cytometry of asynchronous proliferating cell populations produces data with an extractable time-base...
Cytometry of asynchronous proliferating cell populations produces data with an extractable time-base...
<p>Overlays of expression profiles for PHH3 (A, B) from the data set Molt4 cells stained for cyclin ...
<p>Model outputs were normalized to zero and one prior to plotting. cycB = total B cyclin; cycA = to...
<p>The cytometric data for HeLa, K562, and RKO cells (<a href="http://www.plosone.org/article/info:d...
<p><b>A, B, D, E, F</b>: total simulated levels (bound and free, inactive and active) of cyclins A a...
<p>Relative expression data of D-type cyclins (purple triangles) and B-type cyclins (green rhombuses...
<p>PHH3 (green) and cyclin A2 (red) profiles, extracted from single cyclin sample data, are co-plott...
<p>Normalized expression profiles of cyclin A2 (<b>A</b>), cyclin B1 (<b>B</b>), and PHH3 (<b>C</b>)...
<p>DNA histograms from K562 cells stained for single cyclins A2 (B) or B1 (C) or stained for both cy...
<p>Percent of cells in each cell cycle phase as determined by FACS analysis at (<b>A</b>) 0 h; (<b>B...
<p><b>A</b>: Schematic derived from the Csikasz-Nagy model <a href="http://www.plosone.org/article/i...
<div><p>Few of >150 published cell cycle modeling efforts use significant levels of data for tuning ...
<p>(A). Cell cycle profiles showing the distribution of cells in the different phases of the cell cy...
<p>This figure is analogous to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone...
Cytometry of asynchronous proliferating cell populations produces data with an extractable time-base...
Cytometry of asynchronous proliferating cell populations produces data with an extractable time-base...
<p>Overlays of expression profiles for PHH3 (A, B) from the data set Molt4 cells stained for cyclin ...
<p>Model outputs were normalized to zero and one prior to plotting. cycB = total B cyclin; cycA = to...
<p>The cytometric data for HeLa, K562, and RKO cells (<a href="http://www.plosone.org/article/info:d...
<p><b>A, B, D, E, F</b>: total simulated levels (bound and free, inactive and active) of cyclins A a...
<p>Relative expression data of D-type cyclins (purple triangles) and B-type cyclins (green rhombuses...
<p>PHH3 (green) and cyclin A2 (red) profiles, extracted from single cyclin sample data, are co-plott...
<p>Normalized expression profiles of cyclin A2 (<b>A</b>), cyclin B1 (<b>B</b>), and PHH3 (<b>C</b>)...
<p>DNA histograms from K562 cells stained for single cyclins A2 (B) or B1 (C) or stained for both cy...
<p>Percent of cells in each cell cycle phase as determined by FACS analysis at (<b>A</b>) 0 h; (<b>B...
<p><b>A</b>: Schematic derived from the Csikasz-Nagy model <a href="http://www.plosone.org/article/i...
<div><p>Few of >150 published cell cycle modeling efforts use significant levels of data for tuning ...
<p>(A). Cell cycle profiles showing the distribution of cells in the different phases of the cell cy...