Orientation bias indices (OBIs) for NR and GR mice and sensitivity profile for orientation plasticity.

<p>(A) Averaged OBIs obtained from intrinsic signal imaging of NR and GR groups for juvenile and adult mice. (B) Averaged OBIs obtained from two-photon imaging of juvenile NR and GR groups. (C) Age dependence of OBIs averaged among animals of the same age for NR and GR mice. The dashed gray line indicates OBI = 0.5, corresponding to the absence of any representation bias towards the vertical or horizontal orientation. Faint dots indicate OBIs for individual mice. Error bars indicate SE. Significant differences in OBIs for GR and NR mice are shown as *p<0.05, **p<0.01 and ***p<0.001. (D) Sensitivity profile for orientation plasticity induced by the one-week of exposure to vertical orientation from 3w to 15w. The critical period for orientation plasticity is suggested to lie between 4w and 7w, during which the sensitivity index (SI) is prominently large. Also, orientation plasticity is found to be preserved to some extent even after 12w.