Systemic LT reduces RBC velocity in mesentery capillaries in B6.CAST.11M mice.

<p>RBC velocities within capillaries were determined as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040126#pone-0040126-g002" target="_blank">Fig 2</a> for animals given an i.p. injection of <b>A</b>) saline or <b>B</b>) LT. Points represent the average velocity of the RBCs in the three areas within each loop at the indicated times (12 points = 4 intestinal loops × 3 repetitions/loop). Regression lines were calculated from these 12 points/mouse group. Error bars represent standard error of the mean. <b>C</b>) The area under regression lines for animals given saline (corresponding to panel A) or LT (corresponding to panels B) (# indicates arbitrary units). Error bars represent standard error of the mean. Area under the curve is considered an informative measure of overall disease activity <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040126#pone.0040126-Fleming1" target="_blank">[91]</a>. The area under regression lines was less in B6.CAST.11M mice receiving LT compared to C57BL/6J mice receiving LT (p<0.001) or B6.CAST.11M mice receiving saline (p<0.001). The area under the curve was not statistically different between B6.CAST.11M and C57BL/6J mice given saline. (C57BL/6J given saline, n = 4; B6.CAST.11M given saline, n = 6; C57BL/6J mice given LT, n = 5; and B6.CAST.11M given LT, n = 8).